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Josef is currently the Director of the Life Sciences Institute at the University of British Columbia and was the founding Scientific Director of the Institute of Molecular Biotechnology of the Austrian Academy of Sciences. He co-authored over 700 publications and is an inventor on several patents. Josef received numerous awards, including the Wittgenstein Prize of the Austrian Federal Government, the Descartes Prize for Research, the Ernst Jung Prize for Medical Excellence, the Innovator Award of the US Department of Defense, and the Austrian Cross of Honor for Science and Art First Class.

Josef studied medicine at the University of Innsbruck in Austria and worked at the Ontario Cancer Institute as a post-doctoral fellow, before becoming Principal Investigator at the Amgen Institute and Associate Professor at the Departments of Immunology and Medical Biophysics in Toronto.