Vascular transplants

Background

Blood vessels are the lifelines of our body, supplying tissue with oxygen and nutrients. Wounds are disconnected from the blood supply and require a re-establishment of blood flow to heal. This fails in several types of severe wounds, negatively impacting wound closure.

Approach

Our technology allows us to grow small human blood vessels in the lab. If successful, they can be transplanted into wounds. The blood vessels will reconnect the tissue to the blood supply and allow normal wound healing to take place.
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Applications

Chronic wounds

Severe burns

Tissue vascularization

Angios technology

Blood VesselOrganoids (BVOs) as a regenerative cell-based therapy

Angios has developed a patented protocol to generatehuman blood vessels in a petridish. These “organoids” accurately recapitulate the composition and architecture of human micro-vasculature. Upon transplantation into a living organism, BVOs can connect with the host vasculature and become part of it, there by highlighting their potential in regenerative transplantation medicine. Initial experimentsat Angios have reviealed that transplantation of BVOs in the wounds of mice, leads to accelerated healing capability. We are currently adapting our BVO production protocols to meet the high quality and safety standards, required for entering clinical trials. Our goal is to use BVOs at large scale for chronic non-healing wounds, such as ones found in diabetes patients. Upon transplantation, the BVOs will kick-start a healing process, allowing for faster wound closure and tissue regeneration.

The vascular transplants are
“blood vessel factories”

Connect to perfused vasculature

Transplanted vascular organoids efficiently connect to the murine vasculature. The human blood vessels are efficiently perfused. Connection to in vivo blood flow induces maturation

Therapeutic potential

Diabetes can cause a decelerated healing of acquired wounds.

In some cases, these wounds cease to heal completely, causing pain, disability and increased mortality, thus severely affecting the quality of life. We believe that replenishing the wounds with oxygen by transplanting lab-grown blood vessels, normal wound healing will be able to resume.

Our Vision